Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
(3)
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
(9)
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Ligands for Target Protein for PROTAC Ligands
(12)
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Ligands for Target Protein for PROTAC Related Products (686)
Related Products (686)
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Related Compound Screening Libraries (1)
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SLF-amido-C2-COOH (Standard)
0 ImagesCat. No.: HY-107452RCAS No.: 1092369-24-8Synonyms: PROTAC FKBP12-binding moiety 1 (Standard)SLF-amido-C2-COOH (Standard) is the analytical standard of SLF-amido-C2-COOH (HY-107452). This product is intended for research and analytical applications. SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs.
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SMARCA2 ligand-6
0 ImagesCat. No.: HY-159542CAS No.: 2408394-89-6
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Apcin-A monohydrochloride
0 ImagesCat. No.: HY-W614725CAS No.: 1683535-53-6
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Dasatinib carbaldehyde (Standard)
0 ImagesCat. No.: HY-111857RCAS No.: 2112837-79-1Synonyms: BMS-354825 carbaldehyde (Standard); PROTAC ABL binding moiety 4 (Standard)Dasatinib carbaldehyde (Standard) is the analytical standard of Dasatinib carbaldehyde (HY-111857). This product is intended for research and analytical applications. Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
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BCL-xL ligand 3
0 ImagesCat. No.: HY-185551CAS No.: 3053404-37-5BCL-xL ligand 3 is a BCL-xL PROTAC ligand. BCL-xL ligand 3 can be conjugated with E3 ligase Ligand (HY-112078) and linker to synthesize PROTAC Bcl-xL degrader-3 (HY-132997).
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DUPA (Standard)
0 ImagesCat. No.: HY-111606RCAS No.: 302941-52-2DUPA (Standard) is the analytical standard of DUPA (HY-111606). This product is intended for research and analytical applications. DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in agent conjugate to selectively deliver cytotoxic agents to prostate cancer cells.
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(R)-I-BET762 carboxylic acid (Standard)
0 ImagesSynonyms: (R)-Molibresib carboxylic acid (Standard); (R)-GSK525762A carboxylic acid (Standard); (R)-PROTAC BRD4-binding moiety 2 (Standard)(R)-I-BET762 carboxylic acid (Standard) is the analytical standard of (R)-I-BET762 carboxylic acid (HY-107443A). This product is intended for research and analytical applications. (R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1.
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(+)-JQ-1 (Standard)
0 ImagesCat. No.: HY-13030RCAS No.: 1268524-70-4Synonyms: JQ1 (Standard)(+)-JQ-1 (Standard) is the analytical standard of (+)-JQ-1 (HY-13030). This product is intended for research and analytical applications. (+)-JQ-1 (JQ1), a chemical probe, is a potent, specific, CNS-penetrant and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
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BRAF ligand-1
0 ImagesCat. No.: HY-41747CAS No.: 2413037-31-5
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(4R,5S)-RG7112D
0 ImagesCat. No.: HY-158685A(4R,5S)-RG7112D is an isomer of RG7112D (HY-158685). The IC50 values of RG7112D for inhibiting MDM2-p53 and VHL-HIF1α are 11 nM and >10000 nM, respectively. (4R,5S)-RG7112D can be used in studies related to PROTAC synthesis, for example, serving as the target protein ligand of (4R,5S)-YX-02-030 (HY-158684A).
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SOS1 Ligand intermediate-5
0 ImagesCat. No.: HY-161655CAS No.: 3043923-70-9SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).
